IMPORTANT INFORMATION
Use caution when driving an automobile, operating machinery, or performing other hazardous activities. Metaxalone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking metaxalone.

WHAT IT IS
Metaxalone is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Metaxalone is typically used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Metaxalone may also be used for purposes other than those listed here.

HOW TO USE THIS MEDICATION
Take metaxalone exactly as indicated by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Store metaxalone at room temperature away from moisture and heat.

SIDE EFFECTS
If you experience any of the following serious side effects, stop taking metaxalone and seek emergency medical attention immediately: an allergic reaction, such as difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or yellow tint of the skin or eyes. Other, less serious side effects may be more likely to occur. Continue to take metaxalone and talk to your doctor if you experience drowsiness or dizziness; headache, nervousness, or irritability; nausea, upset stomach, or vomiting. Side effects in addition to those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially troublesome.

PRECAUTIONS
Use caution when driving an automobile, operating machinery, or performing other hazardous activities. Metaxalone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking metaxalone.

DRUG INTERACTIONS
Many drugs can amplify the effects of metaxalone, which can lead to heavy sedation. Before taking this medication, inform your doctor if you are taking any of the following medicines: · antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others; · narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others); sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal); · phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or · antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate). o Drugs other than those listed here may also interact with metaxalone. Inform your doctor and pharmacist before taking any prescription or over-the-counter medicines.

MISSED DOSE
You should take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication under any circumstances.

IF YOU TAKE TOO MUCH
Seek emergency medical attention immediately. Symptoms of a metaxalone overdose are unknown but might include low blood pressure (weakness, fainting, confusion), nausea, severe drowsiness, decreased breathing, and unconsciousness.